Translating the genome into function.

Our group is a computational systems biology research team, integral to translational research at Beth Israel Deaconess Medical Center. Combining classical genome discovery approaches with systems biology, we work onĀ systems RNA medicine as part of the Precision Medicine Initiative at BIDMC and together with the RNA Precision Medicine Core .

We are in the dawn of a new era of RNA therapeutics in which precisely targeted RNA molecules exert powerful effects to selectively eliminate cancer cells, restore homeostasis or address disease processes with minimal side-effects. Also, systems biology approaches to understanding function are supporting powerful new drug target discovery programmes. We explore both the possibilities and the reality of bringing together these novel paradigms to forge new high precision medicines.

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Through formalization of in silico systems approaches to understanding of the complex interplay of pathways and processes, my group is a driver in the field of data-driven systems approaches to disease causal discovery. We continue to make important contributions to this aspect in target/drug prioritization. We develop systems-based approaches to coding and noncoding RNA drug and target development, discovery, and enhancement of activity of pathways that appear to confer resilience against disease. We intend to continue to be at the forefront of this emerging field, translating discoveries in the mechanisms of disease into more effective drug treatments for both treatment and prevention. We hope to continue mapping the interplay between dysregulation of canonical pathways, disease and resilience signatures, and definition of specific drug combinations against target pathways.