Translating the genome into function.

Our group is a computational systems biology research team, integral to translational research at Beth Israel Deaconess Medical Center. Combining classical genome discovery approaches with systems biology, and together with the RNA Precision Medicine Core we work on systems RNA medicine as part of the Precision Medicine Initiative at BIDMC.

Systems biology approaches to understanding function are supporting powerful new drug target discovery programmes. We explore both the possibilities and the reality of bringing together these novel paradigms to forge new high precision medicines.

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Through formalization of in silico systems approaches to understanding of the complex interplay of pathways and processes, my group is a driver in the field of data-driven disease causal discovery. We develop systems-based approaches to coding and noncoding RNA drug and target development, discovery, and enhancement of activity of pathways that appear to confer resilience against disease. We hope to continue mapping the interplay between dysregulation of canonical pathways, disease and resilience signatures, and definition of specific drug combinations against target pathways. 

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