What pathways are active in your data? How do they group together to drive functions? What miRNAs regulate them?
Pathways work together – just how is the problem. One neat way to figure out what functions are made up is to see how pathways co-activate. When groups of them show similar activation, they form a module of function. A neat aspect of miRNAs is that they tend to modulate “functions” – at least at the level of preferring to modulate gene expression of genes that have products that interact . So it’s natural that interacting pathways, with formal roles in function, attract common miRNAs. We have built a tool to expose these events – and so open the door to a new view on functional interaction. Using Panomir you can find
- What pathways are activated in your data
- How they interact together
- Find modules of interacting pathways and their prioritized targeting miRNAs
Pourya Naderi Yeganeh, Yue Y Teo, Dimitra Karagkouni, Yered Pita-Juárez, Sarah L Morgan, Frank J Slack, Ioannis S Vlachos, Winston A Hide
This work has taken us quite a while – Driven by Pourya Naderi Yagneh our team and Ioannis Vlachos team.