Some key publications

Complete List of Published Work in My Bibliography:

My group developed the first systems-level synthesis of pathway and network activity across species and platforms to discover 4 common self-renewal pathways in acute myeloid leukemia in mouse and man. Defining pathways by correlated activity, I discovered large scale interaction between pathways and known Alzheimer’s Disease genes. Expanding pathway correlation to drug responses and diseases we established a powerful new paradigm by using pathways in children resilient to sepsis to successfully discover drugs that drive resilience in a mouse model. This work has made it possible, for the first time, to systematically define and drug the pathways that control disease.

Altschuler GM, Hofmann O, Kalatskaya I, Payne R, Ho Sui SJ, Saxena U, Krivtsov AV, Armstrong SA, Cai T, Stein L, Hide WA. Pathprinting: An integrative approach to understand the functional basis of disease. Genome Med. 2013;5(7):68. PubMed PMID: 23890051; PubMed Central PMCID: PMC3971351

Joachim RB, Altschuler GM, Hutchinson JN, Wong HR, Hide WA, Kobzik L. The relative resistance of children to sepsis mortality: from pathways to drug candidates. Mol Syst Biol. 2018 May 17;14(5):e7998. PubMed PMID: 29773677

Pita-Juárez Y, Altschuler G, Kariotis S, Wei W, Koler K, Green C, Tanzi RE, Hide W. The Pathway Coexpression Network: Revealing pathway relationships. PLoS Comput Biol. 2018 Mar;14(3):e1006042. PubMed PMID: 29554099; PubMed Central PMCID: PMC5875878

Using network relationships to understand influence of key regulatory miRNAs I was co-discoverer of the role of miR-24 in inhibiting cell proliferation by targeting E2F2 and MYC and the role of miR-34a as a regulator of growth factor signaling. I was co-discoverer of the role of proteasome degradation in controlling proliferation in breast cancer cells. This has established the role of integrative network analysis in functional understanding of micro-RNA’s

Lal A, Thomas MP, Altschuler G, Navarro F, O’Day E, Li XL, Concepcion C, Han YC, Thiery J, Rajani DK, Deutsch A, Hofmann O, Ventura A, Hide W, Lieberman J. Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS Genet. 2011 Nov;7(11):e1002363. PubMed PMID: 22102825; PubMed Central PMCID: PMC3213160

Lal A, Navarro F, Maher CA, Maliszewski LE, Yan N, O’Day E, Chowdhury D, Dykxhoorn DM, Tsai P, Hofmann O, Becker KG, Gorospe M, Hide W, Lieberman J. miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to “seedless” 3’UTR microRNA recognition elements. Mol Cell. 2009 Sep 11;35(5):610-25. PubMed PMID: 19748357; PubMed Central PMCID: PMC2757794

Petrocca F, Altschuler G, Tan SM, Mendillo ML, Yan H, Jerry DJ, Kung AL, Hide W, Ince TA, Lieberman J. A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells. Cancer Cell. 2013 Aug 12;24(2):182-96. PubMed PMID: 23948298; PubMed Central PMCID: PMC3773329

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